In general, all sources tend to agree that agonist and antagonist are antonyms. With the caveat that this may describe endogenous ligands as well as drugs. "Antagonist: A drug that reduces the action of another drug" The International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification ( Neubig et al, 2003) give an "official" definition as Receptor antagonists bind to receptors but do not activate them the primary action of antagonists is to reduce the effects of agonists". "In the presence of a fixed concentration of agonist, increasing concentrations of a competitive antagonist progressively inhibit the agonist response. The chapter in Katzung (14th ed.) doesn't so much define an agonist or antagonist, but rather describes what they do:
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